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2026, Vol. 46 No. 10 Published:20 October 2026
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• Upgrading the scientific research paradigm of integrated traditional Chinese and Western medicine: from "single-target" validation to "state-target causality" validation [ 2285-2295 ]
  Qingfeng DU, Xiaolin TONG

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• Association between depressive symptoms and renal hyperfiltration in middle-aged and older adults [ 2296-2308 ]
  Mengdi YANG, Hongtao YIN, Hongli LI, Qiong LI, Xiao JI, Donghu ZHEN

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• Shenqi Xiezhuo Decoction ameliorates renal fibrosis in rats by inhibiting excessive autophagy via modulating the ERK1/2-mTOR signaling pathway [ 2309-2324 ]
  Xiaoyu LU, Tianxiao PANG, Ye LIU, Xuehong HE, Zhiming LI

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• 40 Hz flicker light stimulation suppresses STING signaling to improve cognitive dysfunction in mice with Parkinson disease [ 2325-2337 ]
  Qianqian REN, Baowen ZHANG, Xingran LIU, Weili DING, Dandan CHEN, Xianjuan KOU

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• PGAM5 deficiency attenuates atherosclerosis, enhances oxidized LDL uptake by liver sinusoidal endothelial cells and reshapes circulating lipidome in mice [ 2338-2356 ]
  Huixin TAN, Junguo JIN, Manqi YANG, Jingli WANG, Fenghua ZHOU, Ping ZENG, Xuegang SUN

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• Role of Ddx56 gene associated with early-onset Parkinson disease in maintaining neural development and protecting against dopaminergic neuron apoptosis in zebrafish [ 2357-2371 ]
  Qian XU, Erqi LIU, Qiaofeng ZHANG, Haixin LIU, Xinpei LIN, Yao LIN

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• Gag^p17 protein KSKK→KSQQ substitution and ΔKSKK deletion mutations promote HIV-1 release and Gag^p17 maturation in HIV-1 CRF55_01B and CRF59_01B strains [ 2372-2383 ]
  Zebin ZHOU, Yulin YANG, Huanchang YAN, Xin WAN, Zhirou LEI, Haiying WANG, Shixing TANG

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• Lead exposure aggravates Aβ_1-42-induced microglial activation through mitochondrial calcium uniporter-mediated mitochondrial calcium accumulation [ 2384-2392 ]
  Lixuan CHEN, Yanpei LONG, Dingbang HUANG, Gang ZHENG, Xiaojing MENG

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• Schisandrin A alleviates neuronal ferroptosis in mice with hypoxic-ischemic brain injury by inhibiting the ACSL4/TFRC/PTGS2 signaling pathway [ 2393-2404 ]
  Tao GUO, Jiahao HE, Yuexin DONG, Zhao WANG, Hanjun ZUO, Yanli ZHAO, Jinsha SHI, Min ZHAO, Juanjuan LI

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• Myocardium global longitudinal strain and peripheral blood neutrophil-to-lymphocyte ratio for predicting MACE risks following percutaneous coronary intervention for first-time acute myocardial infarction: a prospective cohort study [ 2405-2414 ]
  Mengru HE, Chuan JIN, Yixuan YU, Jingxian WANG, Xu TONG, Muyan CHEN, Hongwei SONG, Ying WANG, Li ZHOU, Jun WANG, Hongju WANG, Miaonan LI

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• CEBPA promotes hepatic steatosis in metabolic dysfunction-associated fatty liver disease in mice via the SREBP-1c/FASN/ACC axis [ 2415-2423 ]
  Leiying ZHANG, Liyang ZOU, Lingling ZHOU, Xin MA, Xiaomin LIU, Huan YAO, Yuan ZHUANG, Yang YU

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• Sphingomyelin phosphodiesterase 1 knockdown promotes exogenous dihomo-γ-linolenic acid-induced ferroptosis in acute myeloid leukemia cells [ 2424-2433 ]
  Yingying HUANG, Wei WU, Xiaoying HONG, Xiandong JIANG, Yan XUE, Donghong LIN

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• Jiawei Qingluo Yin alleviates rheumatoid arthritis in rats by inhibiting activation of the Hedgehog signaling pathway to promote apoptosis of synovial cells [ 2434-2446 ]
  Yifei HAO, Lianqing CAI, Siyu TANG, Xiaoxuan YU, Yan LI, Xiu WANG, Jie ZHU

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• Suanzaoren Decoction inhibits neuroinflammation and alleviates hippocampal neuronal injury in APP/PS1 transgenic mice by regulating the Hippo-YAP pathway [ 2447-2455 ]
  Qixuan NIU, Dan WU, Bixuan LAI, Junhua CHEN, Zhengyu WANG, Qinghua LONG

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• Construction of predictive models for type 2 diabetic retinopathy based on the principle of differentiation of syndrome elements [ 2456-2470 ]
  Shijie QIAO, Jinshun YOU, Chang WANG, Hongping XIONG, Shunan LI

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• Positive association of exposure to per- and polyfluoroalkyl substances with arterial stiffness parameters and its interaction with sex hormone levels [ 2471-2481 ]
  Chaoyuan ZHENG, Yinglei YU, Haoyan ZHANG, Ying LI, Bing GUO

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• Aerobic exercise improves metabolic disorders and multi-organ damage in diabetic rats by activating the Sirt1/Creb1/Ppargc1a axis [ 2482-2493 ]
  Guannan ZHANG, Xiang LI, Yuan MI, Danyang TIAN, Jinqi MENG

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• LGALS3 is an efferocytosis-related biomarker and potential traditional Chinese medicine therapeutic target for diabetic kidney disease complicated with heart failure [ 2494-2508 ]
  Dunlin HU, Hui GUO, Xiaojuan WANG, Yu LI, Chi ZHANG, Xiaohu CHEN, XiaoLi NIE

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• Jiaotaiwan improves lipid metabolism abnormalities in a mouse model of Alzheimer disease by regulating the AMPK signaling pathway [ 2509-2517 ]
  Yuqing RUAN, Can CUI, Jingzhe LI, Yan WANG, Xiu WANG

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• Comparison of Pulsatilla decoction formula granules versus its standard decoction for consistency of chemical components and bioequivalence in mice with ulcerative colitis [ 2518-2535 ]
  Jiana ZHANG, Xia ZHANG, Weixuan HUANG, Dandan YE, Zhuowen HUANG, Jinhao HUANG, Xiaoya WENG, Lin PENG, Weibo DAI, Xiaoqi HUANG

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• Syringin improves myocardial mitochondrial dynamics and alleviates oxidative stress injury in septic mice by activating SIRT3 [ 2536-2547 ]
  Yan LIU, Hongqi ZHANG

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• Withaferin A inhibits biofilm formation and adhesion of neonatal meningitis Escherichia coli by downregulating ibeR expression [ 2548-2557 ]
  Zhengying YU, Bingliang ZHOU, Xiangshun MENG, Lei WANG, Shenghe HUANG, Hong CAO

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• Transarterial embolization microspheres for liver cancer: current applications and advances [ 2558-2574 ]
  Lun LI, Yuqin ZHANG, Qingli ZHAN, Wei ZHAO, Junbing FAN

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• Chronic pain: from central sensitization to network homeostasis imbalance [ 2575-2590 ]
  Cailian RUAN, Xueting YANG, Jingyi ZHANG, Tongjie TENG, Zhenghao CHEN, Yuhan LIU, Ying YANG, Yayun WANG

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