南方医科大学学报

南方医科大学学报 ›› 2025, Vol. 45 ›› Issue (6): 1336-1342.doi: 10.12122/j.issn.1673-4254.2025.06.23

• • 上一篇    下一篇

基于双极读出梯度的单重复时间腰椎定量磁化率成像

董振翔1,2(), 郭义昊1,2, 刘蔷1,2, 张益哲1,2, 丘倩怡3, 张晓东3, 冯衍秋1,2()   

  1. 1.南方医科大学，生物医学工程学院，广东 广州 510515
    2.南方医科大学，广东省医学图像处理重点实验室，广东 广州 510515
    3.南方医科大学第三附属医院广东省骨科研究院影像科，广东 广州 510630
  • 收稿日期:2025-03-13 出版日期:2025-06-20 发布日期:2025-06-27
  • 通讯作者: 冯衍秋 E-mail:3464737526@qq.com;foree@163.com
  • 作者简介:董振翔，在读硕士研究生，E-mail: 3464737526@qq.com
  • 基金资助:
    国家自然科学基金(82372079);广东省自然科学基金(2024A1515010014);国家自然科学基金联合基金(U21A6005)

A single repetition time quantitative magnetic susceptibility imaging method for the lumbar spine using bipolar readout gradient

Zhenxiang DONG1,2(), Yihao GUO1,2, Qiang LIU1,2, Yizhe ZHANG1,2, Qianyi QIU3, Xiaodong ZHANG3, Yanqiu FENG1,2()   

  1. 1.School of Biomedical Engineering, Guangdong Provincial Orthopedic Research Institute, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China
    2.Guangdong Provincial Key Laboratory of Medical Imaging Processing, Southern Medical University, Guangzhou 510515, China, Guangdong Provincial Orthopedic Research Institute, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China
    3.Department of Imaging, Guangdong Provincial Orthopedic Research Institute, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China
  • Received:2025-03-13 Online:2025-06-20 Published:2025-06-27
  • Contact: Yanqiu FENG E-mail:3464737526@qq.com;foree@163.com
  • Supported by:
    National Natural Science Foundation of China(82372079)

RichHTML

14

PDF

87

摘要：

目的 提出一种利用双极读出梯度的单重复时间（TR）腰椎定量磁化率成像方法，并比较单TR与双TR方法在不同腰椎骨密度受试者的定量磁化率结果。 方法 提出平移校正方法解决了正负梯度读出图像之间沿频率编码方向空间错位问题，提出相位校正方法消除正负梯度读出图像之间的相位差。使用单TR和双TR方法采集了6名正常人，2名骨质减少患者以及2名骨质疏松患者的腰椎L1-L5的数据，重建出磁化率图后，将校正前后单TR与双TR方法的定量结果进行比较。 结果 单TR方法校正前与双TR方法所得腰椎磁化率值的线性回归结果为：Y=0.64*X-11.61。单TR方法校正后与双TR方法腰椎磁化率值的线性回归结果为：Y=1.03*X+0.25。说明校正后的单TR方法与双TR方法的结果高度一致，并且校正后的单TR方法能够有效地区分正常、骨量减少及骨质疏松患者。 结论 经过校正的单TR双极读出梯度方法能够生成无伪影的腰椎定量磁化率分布图，并且将数据采集时间缩短了50%。

关键词: 磁共振成像, 定量磁化率成像, 单重复时间, 腰椎, 骨质疏松

Abstract:

Objective To propose a single repetition time (TR) quantitative magnetic susceptibility imaging method for the lumbar spine using bipolar readout gradient, and compare the quantitative magnetic susceptibility measurement using single TR and dual TR methods for the lumbar spine with different bone densities. Methods A translation correction method was proposed to correct spatial misalignment along the frequency encoding direction between positive and negative gradient readout images, and the phase difference between the images was eliminated using a phase correction method. The data of lumbar vertebrae L1-L5 were collected using single TR and dual TR methods from 6 normal individuals, 2 patients with osteopenia, and 2 patients with osteoporosis. The magnetic susceptibility map was reconstructed, the quantitative results of single TR before and after correction were compared with those of the dual TR method. Results The linear regression result of the lumbar spine magnetic susceptibility values obtained by the single TR method before calibration and the dual TR method is Y=0.64*X-11.61. The linear regression result of the lumbar spine magnetic susceptibility values corrected by the single TR method and the dual TR method is Y=1.03*X+0.25. The results of the corrected single TR method were highly consistent with those of the dual TR method, and the calibrated single TR method could effectively distinguish osteopenia and osteoporosis patients from normal individuals. Conclusion The calibrated single TR bipolar readout gradient method can generate artifact-free lumbar spine quantitative magnetic susceptibility distribution maps and reduce data acquisition time by 50%.

Key words: magnetic resonance imaging, quantitative susceptibility mapping, single TR, lumbar spine, osteoporosis