Journal of Southern Medical University ›› 2026, Vol. 46 ›› Issue (5): 1093-1101.doi: 10.12122/j.issn.1673-4254.2026.05.13
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SENP1 reduces ferroptosis of thyroid cancer cells by regulating hypoxia-inducible factor-1α
Feifei ZHU1(
), Na YAN1, Jiwen YANG2, Xiaolei CHEN2, Yingying WANG2()
- 1.Department of Ultrasound, The First Affiliated Hospital of Wannan MedicalUniversity (Yijishan Hospital of Wannan Medical University), Wuhu 241001, China
2.Department of Nuclear Medicine, The First Affiliated Hospital of Wannan MedicalUniversity (Yijishan Hospital of Wannan Medical University), Wuhu 241001, China
-
Received:2025-05-16Online:2026-05-20Published:2026-05-27 -
Contact:Yingying WANG E-mail:570532590@qq.com;850247303@qq.com
Cite this article
Feifei ZHU, Na YAN, Jiwen YANG, Xiaolei CHEN, Yingying WANG. SENP1 reduces ferroptosis of thyroid cancer cells by regulating hypoxia-inducible factor-1α[J]. Journal of Southern Medical University, 2026, 46(5): 1093-1101.
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Fig.1 Sh-SENP1 transfection inhibits tumorigenesis of TPC-1 cells in nude mice. A: Comparison of tumor volume. B: Comparison of tumor weight. C: Dissected tumors from each group. D, E: mRNA expression levels of COX2 and TNF-α in the tumor tissues. F, G: Caspase-3 and -9 activities in the tumor tissues. **P<0.01, ***P<0.001 vs sh-nc (n=6).
Fig.1 Sh-SENP1 transfection inhibits tumorigenesis of TPC-1 cells in nude mice. A: Comparison of tumor volume. B: Comparison of tumor weight. C: Dissected tumors from each group. D, E: mRNA expression levels of COX2 and TNF-α in the tumor tissues. F, G: Caspase-3 and -9 activities in the tumor tissues. **P<0.01, ***P<0.001 vs sh-nc (n=6).
Fig.2 SENP1 overexpression promotes proliferation and migration of TPC-1 cells in vitro. A-F: mRNA expression level of SENP1 (A), cell proliferation (B), cell migration (C, E, original magnification:×40), and EDU-positive cells (D, F, ×40) in different groups. **P<0.01, ***P<0.001 vs negative (n=3).
Fig.2 SENP1 overexpression promotes proliferation and migration of TPC-1 cells in vitro. A-F: mRNA expression level of SENP1 (A), cell proliferation (B), cell migration (C, E, original magnification:×40), and EDU-positive cells (D, F, ×40) in different groups. **P<0.01, ***P<0.001 vs negative (n=3).
Fig.3 SENP1 knockdown inhibits proliferation and migration of TPC-1 cells in vitro. A-F: mRNA expression level of SENP1 (A), cell proliferation (B), cell migration (C, E, ×40), and EDU-positive cells (D, F, ×40) in different groups. *P<0.05, **P<0.01, ***P<0.001 vs si-nc (n=3).
Fig.3 SENP1 knockdown inhibits proliferation and migration of TPC-1 cells in vitro. A-F: mRNA expression level of SENP1 (A), cell proliferation (B), cell migration (C, E, ×40), and EDU-positive cells (D, F, ×40) in different groups. *P<0.05, **P<0.01, ***P<0.001 vs si-nc (n=3).
Fig.4 SENP1 overexpression reduces ferroptosis of TPC-1 cells. A-C: SENP1 overexpression reduces proportion of PI-positive cells, iron content, and protein level of GPX4 in TPC-1 cells. D-F: SENP1 knockdown increases proportion of PI-positive cells, iron content, and protein level of GPX4 in TPC-1 cells. G: SENP1 knockdown increases protein level of GPX4 in tumor tissues of mice. **P<0.01, ***P<0.001 vs Negative, si-nc or sh-nc (n=3).
Fig.4 SENP1 overexpression reduces ferroptosis of TPC-1 cells. A-C: SENP1 overexpression reduces proportion of PI-positive cells, iron content, and protein level of GPX4 in TPC-1 cells. D-F: SENP1 knockdown increases proportion of PI-positive cells, iron content, and protein level of GPX4 in TPC-1 cells. G: SENP1 knockdown increases protein level of GPX4 in tumor tissues of mice. **P<0.01, ***P<0.001 vs Negative, si-nc or sh-nc (n=3).
Fig.5 SENP1 overexpression reduces mitochondrial damage in TPC-1 cells. A-D: SENP1 overexpression increases depolymerization level of JC-1, Calcein-AM/ cobalt chloride, extracellular acidification rate (ECAR), and oxygen consumption rate (OCR). E-H: SENP1 knockdown reduces depolymerization level of JC-1, Calcein-AM/ cobalt chloride, ECAR, and OCR. I, J: Mitochondrial damage in TPC-1 cells detected by electron microscopy (Original magnification: ×10 000). **P<0.01, ***P<0.001 vs Negative or si-nc (n=3).
Fig.5 SENP1 overexpression reduces mitochondrial damage in TPC-1 cells. A-D: SENP1 overexpression increases depolymerization level of JC-1, Calcein-AM/ cobalt chloride, extracellular acidification rate (ECAR), and oxygen consumption rate (OCR). E-H: SENP1 knockdown reduces depolymerization level of JC-1, Calcein-AM/ cobalt chloride, ECAR, and OCR. I, J: Mitochondrial damage in TPC-1 cells detected by electron microscopy (Original magnification: ×10 000). **P<0.01, ***P<0.001 vs Negative or si-nc (n=3).
Fig.6 SENP1 overexpression promotes HIF-1 α protein levels in TPC-1 cells. A-C: SENP1 and HIF-1 α protein levels in TPC-1 cell xenografts in nude mice and in cultured TPC-1 cells. D: Levels of SENP1 and HIF-1 α proteins in cultured TPC-1 cells (immunofluorescence staining, ×500). **P<0.01, ***P<0.001 vs Negative or Si NC or SH NC (n=3).
Fig.6 SENP1 overexpression promotes HIF-1 α protein levels in TPC-1 cells. A-C: SENP1 and HIF-1 α protein levels in TPC-1 cell xenografts in nude mice and in cultured TPC-1 cells. D: Levels of SENP1 and HIF-1 α proteins in cultured TPC-1 cells (immunofluorescence staining, ×500). **P<0.01, ***P<0.001 vs Negative or Si NC or SH NC (n=3).
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