Journal of Southern Medical University ›› 2025, Vol. 45 ›› Issue (5): 1056-1062.doi: 10.12122/j.issn.1673-4254.2025.05.19
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Zihao WANG1(), Lili TAO2, Biqing ZOU1, Shengli AN1(
)
Received:
2024-10-25
Online:
2025-05-20
Published:
2025-05-23
Contact:
Shengli AN
E-mail:wangzihao0101@126.com;1069766473@qq.com
Zihao WANG, Lili TAO, Biqing ZOU, Shengli AN. First 24-hour arterial oxygen partial pressure is correlated with mortality in ICU patients with acute kidney injury: an analysis based on MIMIC-IV database[J]. Journal of Southern Medical University, 2025, 45(5): 1056-1062.
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URL: https://www.j-smu.com/EN/10.12122/j.issn.1673-4254.2025.05.19
Fig.2 Receiver operating characteristic curve analysis of mean partial pressure of arterial oxygen (PaO2) within 24 h after ICU admission and in-hospital mortality of patients with acute kidney injury (AKI).
Fig.3 Statistical analyses of primary and secondary outcomes, Kaplan-Meier survival curves, and relationship between PaO₂ and mortality of the patients. A: Primary and secondary outcomes. B: Kaplan-Meier survival curve for 90-day mortality. C: In-hospital mortality rates of AKI patients in different stages in the two groups (***P<0.001). D: Non-linear relationship between PaO₂ and in-hospital mortality. E: Non-linear relationship between PaO₂ and 90-day mortality.
Outcome | Total | PaO2≥137.029 mm Hg | PaO2<137.029 mm Hg | P |
---|---|---|---|---|
Before PSM | ||||
Patients (n) | 18 335 | 8565 | 9770 | |
In-hospital mortality [n (%)] | 3099 (16.9) | 840 (9.8) | 2259 (23.1) | <0.001 |
90-day mortality [n (%)] | 3342 (18.2) | 912 (10.6) | 2430 (24.9) | <0.001 |
CRRT [n (%)] | 312 (1.7) | 86 (1.0) | 226 (2.3) | <0.001 |
RRT [n (%)] | 1068 (5.8) | 282 (3.3) | 786 (8.0) | <0.001 |
Duration of ventilator [h, median (IQR)] | 41.0 (17.0-103.7) | 16.0 (7.8-40.0) | 23.0 (10.6-70.0) | <0.001 |
Duration of vasopressor [h, median (IQR)] | 29.4 (11.3-67.4) | 14.1 (3.7-35.0) | 19.4 (6.0-48.9) | <0.001 |
LOS Hospital (day) | 9.0 (5.0-16.0) | 8.0 (5.0-13.0) | 8.0 (5.0-15.0) | <0.001 |
LOS ICU (day) | 3.2 (1.9-6.6) | 2.3 (1.3-4.6) | 2.9 (1.6-5.6) | <0.001 |
After PSM | ||||
Patients (n) | 8838 | 4419 | 4419 | |
In-hospital mortality [n (%)] | 1494 (16.9) | 672 (15.2) | 822 (18.6) | <0.001 |
90-day mortality [n (%)] | 1616 (18.3) | 724 (16.4) | 892 (20.2) | <0.001 |
CRRT [n (%)] | 142 (1.6) | 77 (1.7) | 65 (1.5) | 0.310 |
RRT [n (%)] | 502 (5.7) | 234 (5.3) | 268 (6.1) | 0.118 |
Duration of ventilator [h, median (IQR)] | 33.0 (14.8-89.3) | 24.0 (11.0-68.5) | 28.0 (12.7-79.0) | <0.001 |
Duration of vasopressor [h, median (IQR)] | 23.8 (8.6-57.4) | 20.5 (6.3-53.0) | 22.2 (7.4-55.4) | 0.068 |
LOS Hospital | 9.0 (6.0-16.0) | 9.0 (5.0-15.0) | 9.0 (5.0-16.0) | 0.008 |
LOS ICU | 3.3 (1.9-6.8) | 3.0 (1.7-6.0) | 3.1 (1.8-6.4) | <0.001 |
Tab.1 Outcomes of the patients in the two groups before and after matching
Outcome | Total | PaO2≥137.029 mm Hg | PaO2<137.029 mm Hg | P |
---|---|---|---|---|
Before PSM | ||||
Patients (n) | 18 335 | 8565 | 9770 | |
In-hospital mortality [n (%)] | 3099 (16.9) | 840 (9.8) | 2259 (23.1) | <0.001 |
90-day mortality [n (%)] | 3342 (18.2) | 912 (10.6) | 2430 (24.9) | <0.001 |
CRRT [n (%)] | 312 (1.7) | 86 (1.0) | 226 (2.3) | <0.001 |
RRT [n (%)] | 1068 (5.8) | 282 (3.3) | 786 (8.0) | <0.001 |
Duration of ventilator [h, median (IQR)] | 41.0 (17.0-103.7) | 16.0 (7.8-40.0) | 23.0 (10.6-70.0) | <0.001 |
Duration of vasopressor [h, median (IQR)] | 29.4 (11.3-67.4) | 14.1 (3.7-35.0) | 19.4 (6.0-48.9) | <0.001 |
LOS Hospital (day) | 9.0 (5.0-16.0) | 8.0 (5.0-13.0) | 8.0 (5.0-15.0) | <0.001 |
LOS ICU (day) | 3.2 (1.9-6.6) | 2.3 (1.3-4.6) | 2.9 (1.6-5.6) | <0.001 |
After PSM | ||||
Patients (n) | 8838 | 4419 | 4419 | |
In-hospital mortality [n (%)] | 1494 (16.9) | 672 (15.2) | 822 (18.6) | <0.001 |
90-day mortality [n (%)] | 1616 (18.3) | 724 (16.4) | 892 (20.2) | <0.001 |
CRRT [n (%)] | 142 (1.6) | 77 (1.7) | 65 (1.5) | 0.310 |
RRT [n (%)] | 502 (5.7) | 234 (5.3) | 268 (6.1) | 0.118 |
Duration of ventilator [h, median (IQR)] | 33.0 (14.8-89.3) | 24.0 (11.0-68.5) | 28.0 (12.7-79.0) | <0.001 |
Duration of vasopressor [h, median (IQR)] | 23.8 (8.6-57.4) | 20.5 (6.3-53.0) | 22.2 (7.4-55.4) | 0.068 |
LOS Hospital | 9.0 (6.0-16.0) | 9.0 (5.0-15.0) | 9.0 (5.0-16.0) | 0.008 |
LOS ICU | 3.3 (1.9-6.8) | 3.0 (1.7-6.0) | 3.1 (1.8-6.4) | <0.001 |
Groups | N | Outcomes | OR | 95% CI | P |
---|---|---|---|---|---|
Sensitivity analysis A | 7282 | In-hospital | 0.84 | 0.75-0.95 | 0.006 |
90-day | 0.85 | 0.76-0.96 | 0.007 | ||
Sensitivity analysis B | 7475 | In-hospital | 0.84 | 0.74-0.95 | 0.004 |
90-day | 0.84 | 0.74-0.94 | 0.003 |
Tab.2 Sensitivity analysis of the two groups before and after matching
Groups | N | Outcomes | OR | 95% CI | P |
---|---|---|---|---|---|
Sensitivity analysis A | 7282 | In-hospital | 0.84 | 0.75-0.95 | 0.006 |
90-day | 0.85 | 0.76-0.96 | 0.007 | ||
Sensitivity analysis B | 7475 | In-hospital | 0.84 | 0.74-0.95 | 0.004 |
90-day | 0.84 | 0.74-0.94 | 0.003 |
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