Abstract: Objective To detect serum content of cofilin protein in patients with lung cancer and investigate its clinical value.
Methods The serum content of cofilin protein was detected in 30 cases of lung cancer and 30 healthy control subjects using
enzyme-linked immunosorbent assay. Results The mean serum content of cofilin protein was 0.485±0.465 ng/ml in patients
with lung cancer and 0.203±0.102 ng/ml in the control subjects, showing a significant difference between them (P<0.05). The
content of cofilin protein in patients with stage III and IV lung cancer 0.744±0.584 ng/ml, significantly higher than that in stage
II patients (0.257±0.126 ng/ml). Conclusion Serum cofilin protein is elevated in patients with lung cancer, especially in cases in
advanced stages, suggesting its relation with lung cancer staging.