Abstract: Objective To investigate the effects of topical treatment with adenovirus-mediated promyelocytic leukemia gene
(PML) gene in a psoriasis-like mouse model. Methods The effect of adenovirus-mediated PML gene on the granular layer of
mouse tail scale epidermis and epithelial mitosis were observed on longitudinal histological sections prepared from the tail
skin and vaginal epithelium of the mice. Results Adenovirus-mediated PML gene significantly inhibited mitosis of mouse
vaginal epithelial cells and promoted the formation of granular layer in mouse tail scale epidermis. Conclusion The
therapeutic effect of PML gene in the psoriasis-like mouse model may be associated with increased granular cells and
suppressed epidermic cell proliferation.