Biocompatibility evaluation of chitosan-g-polyvinylpyrrolidone

Abstract

Abstract: Objective To evaluate the biocompatibility of chitosan-g-polyvinylpyrrolidone as a new scaffold material. Methods The material was tested and measured for water absorption and contact angle, followed by evaluation of the biocompatibility by implantation into rabbits and in vitro cultured with the corneal epithelial cells. Results The water absorption rate of the material reached 1 100% with contact angle of 83°-86°. The results of implantation revealed partial degradation of the material 3 months after implantation, and much collagen and numerous corneal stromal cells appeared on the material without obvious inflammation reactions. In vitro coculture with epithelial cells showed good adhesion of the cells to the material which induced no obvious cytotoxicity. Conclusion The novel chitosan derivative has excellent biocompatibility and can be used as a tissue scaffold material.

CLC Number:

R318
R322.91

DENG Zheng-xing, ZHANG Zhi-xiong, LI Li-hua, ZHOU Chang-ren. Biocompatibility evaluation of chitosan-g-polyvinylpyrrolidone[J]. Journal of Southern Medical University, 2004, 24(06): 639-641,645.

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