Abstract: Objective To evaluate the safety and effectiveness of transumbilical single port laparoscopic cholecystectomy
(TSPLC). Methods A retrospective analysis was conducted for the 141 patients, who received TSPLC by DR. Jian in our
hospital since April 2011 to October 2012, and the operative and postoperative effects of these patients were evaluated by
comparing with that of the conventional laparoscopic cholecystectomy (CLC). Results In the total of 141 TSPLC cases that
included in the study, 3 cases converted to CLC. 2 cases converted to open cholecystectomy. Additionally, 1 case was diagnosed
as an unexplained bowel perforation after operation, fat liquefaction occurred in 2 patients. When comparing with these cases
to 306 CLC patients, there was no obvious statistical difference in the terms of patients’ age, gender, BMI and abdominal
surgery history (P>0.05). Meanwhile, There were similar effects of the two groups of patients on the operation time (28.5±19.3
min vs 33.4±14.2 min，P=0.001), estimate blood loss (6.4±18.9 ml vs 9.8±20.6 ml，P=0.06), the time needed for closing abdomen
(5.1±3.8 min vs 5.8±4.3 min，P=0.06) and postoperative complications (3/141 vs 5/306，P=1.00). However, the TSPLC group was
superior to CLC group in the terms of the conversion rate (2/141 vs 25/306，P=0.001), and postoperative hospitalization (1.2±1.4
d vs 2.6±1.7 d，P<0.01), meanwhile, TSPLC was also superior to LC on the satisfactory degree of operative effect through the
one week‘s follow-up (8.5±1.1 vs 7.9±0.7，P<0.01). Conclusion TSPLC is both safer and more effective than that of CLC, and
thus it is worth adopting in selected hospitals.