Abstract: Objective To study the effect and safety of transarterial embolization (TAE) in the management of massive hemorrhage in the nasopharyngeal and maxillofacial regions. Methods Forty-two cases of massive hemorrhage in the naso-pharyngeal and maxillofacial regions were treated by TAE. Gelfoam particles, polyvinyl acohol particles, and metallic coil were used to for embolism of the external carotid artery, maxillary artery, facial artery, occipital artery, sphenopalatine artery and ascending pharyngeal artery respectively according to the angiographic findings and the region of hemorrhage sites. Results TAE was successfully performed in all the cases, and no recurrence or serious complications were observed in the 3 to 12-month follow-up. Conclusion TAE is safe and effective in the treatment of massive hemorrhage in the nasopharyngeal and maxillofacial regions.