Abstract: Objective To evaluate the clinical value of serum 1,3-beta-D-glucan (BG) and galactomannan (GM) detection for
early diagnosis of invasive aspergillosis (IA) in patients after renal transplantation. Methods Blood samples collected from 69
renal transplant recipients were divided into diagnosis group, clinical diagnosis group, suspected diagnosis group, and
non-infected group for detection of serum BG and GM. Results The mean serum levels of BG in the diagnosis group, clinical
diagnosis group, and suspected diagnosis group were significantly higher than that in non-infected group (P<0.05). The
sensitivity, specificity, and positive and negative predictive values of BG was 69.49%, 70%, 93.18% and 35.71% for IA diagnosis,
respectively. The serum levels of GM in the 3 diagnosis groups were also significantly higher than that in the non-infected
group (P<0.05) with the sensitivity, specificity, and positive and negative predictive values of 84.75%, 90%, 96.15% and 52.63%
for IA diagnosis, respectively. Conclusion Increased serum BG and GM levels can serve as the evidence for early diagnosis of
IA with a high diagnostic sensitivity and specificity in renal transplant recipients..