Abstract: Objective To investigate the risk factors contributing to the development of obstructive sleep apnea hypopnea
syndrome (OSAHS) and sleep hypopnea (SH) in patients with growth hormone-secreting pituitary adenoma (GHPA).
Methods A total of 85 patients with GHPA recruited strictly according to the inclusion and exclusion criteria underwent sleep
monitoring overnight. Clinical manifestations, laboratory data and magnet resonance images were collected for analysis of the
risk factors of GHPA and SH using binary logistic regression analysis. Results The prevalence rate of OSAHS was 62.4% (53/
85), and that of SH was 75.3% (64/85) in the recruited patients with GHPA. Regression analysis showed that age (OR=1.107)
and BMI (OR=1.166) were the risk factors for OSAHS, and BMI (OR=1.334) was the risk factor of SH. Conclusions Ageing and
an increased BMI are independent risk factors for OSAHS and SH in patients with GHPA. Preoperative sleep monitoring
should be routinely conducted to ensure early diagnosis of OSAHS and SH, and patients with GHPA should be advised to
control their body weight to lower the mortality associated with the respiratory system.