Abstract: Objective To investigate the relationship between rs6474051 polymorphism of pleomorphic adenoma gene 1
(PLAG1) and the benign parotid tumor in Chinese Han population in Hainan Province. Methods Sixty-five patients with
benign parotid tumor and 69 healthy volunteers (control) were examined for Rs6474051 polymorphisms of PLAG1 gene by
PCR and sequencing. Results Of the 65 patients with benign parotid tumor, the frequencies of CC, CT, and TT genotypes were
33 (50.8%), 25 (38.5%), and 7 (10.7%), as compared to those of 44 (63.8%), 24 (34.8%), and 1 (1.4%) in the control group (P=0.05).
The allele frequency of C/T was 70%/30% in patients with benign parotid tumor, significantly different from that in the control
group (80.6%/19.4%, P<0.05). Conclusion Rs6474051 polymorphism of PLAG1 gene may be associated with the benign parotid
tumor in Chinese Han population in Hainan Province, and the T allele is probably one of susceptible genes.