Abstract: Objective To investigate the expressions of midkine (MK) and Ki67 in gastric carcinoma (GC) and their relation with
the clinicopathologic characteristics. Methods The expressions of MK and Ki67 in 71 GC and 20 adjacent normal tissues were
evaluated by immunohistochemistry. Results The expressions of MK and Ki67 were significantly higher in GC than in adjacent
normal tissues (76.1% vs 0, and 73.2% vs 5% , respectively, P<0.05). MK and Ki67 expressions were correlated with the
infiltration depth, lymph node metastasis and TNM stage (P<0.05), and a significant correlation was found between MK and
Ki67 expressions (P<0.05). Conclusion GC tissues have high expressions of MK and Ki67, indicating that MK and Ki67 play
important roles in promoting the tumorigenesis and progression of GC.