Abstract: Objective To identify the intergenotype recombination of hepatitis B virus (HBV) in Chinese patients and explore
new recombination types of HBV. Methods Complete genome sequences of HBV from Chinese patients were downloaded
from GenBank and analyzed by Fragment-typing method to screen the potential recombinants, and the breakpoints of
recombination were identified by using Simplot program. Results Thirty-one recombination types including 755 recombinants
were identified from 1642 complete HBV genome sequences, including 22 B/C recombination types with 676 recombinants, 5 C/
D recombination types with 75 recombinants, 3 A/C recombination types with 3 recombinants, and 1 C/I recombination type
with 1 recombinant. Conclusion Of the 31 recombination types comprising 755 recombinants, 4 are novel recombination types
found for the first time. All these recombination types identified in this study involve genotype C.