Abstract: Objective To explore the role of central venous pressure (CVP), global end diastolic volume index (GEDI) and
extravascular lung water index (ELWI) monitoring in patients with septic shock during fluid resuscitation by pulse induced
continuous cardiac output (PiCCO) test. Methods Forty-six patients with severe sepsis and septic shock were enrolled in this
study. Hemodynamic monitoring was performed during fluid resuscitation and the data including CVP, GEDI and ELWI were
collected to analyze their relationship and the clinical values. Results In patients with septic shock, CVP showed a weak linear
correlation with GEDI during fluid resuscitation (r=0.137, P=0.009). In the subgroups stratified with CVP cut-off values of 8
mmHg and 12 mmHg, the correlation coefficient between CVP and GEDI was 0.149 (P=0.029) in CVP<8 mmHg group, 0.075 (P=
0.462) in 8 mmHg≤CVP≤12 mmHg group, and 0.049 (P=0.726) in CVP>12 mmHg group. In the total of 367 data groups
obtained, CVP showed no linear correlation with ELWI (r=0.040, P=0.445). In the CVP subgroups, CVP and ELWI were weakly
correlated in CVP<8 mmHg group (r=0.221, P=0.001), but they showed no correlations in 8 mmHg≤CVP≤12 mmHg and CVP>
12 mmHg groups (r=-0.047, P=0.646; r=0.042, P=0.765). Conclusion There is no significant linear correlation between CVP and
GEDI or between CVP and ELWI in patients with septic shock. CVP can not reflect the circulatory blood volume or the degree
of pulmonary edema.