Abstract: Objective To explore the relationship between HSD11B2 polymorphisms and fetal growth during normal pregnancy.
Methods The HSD11B2 promoter/G-209A, G-194C, G-151A and G-126A genotypes were examined in 33 samples from Chinese
Han subjects by gene sequencing. HSD11B2 (CA)n microsatellite polymorphism in the first intron was detected in blood
samples from 187 maternal and newborn pairs by PCR-capillary electrophoresis. Results All the HSD11B2 promoter/G-209A,
G-194C, G-151A and G-126A genotypes were wild-type GG. The offspring birth weight and any ultrasound parameters
describing late gestational fetal body shape were not significantly different between maternal or fetal SS, SL and LL groups or
combined SS+SL and LL groups. When considering the relevant confounding factors (gestational age at delivery, newborn’s
gender, maternal body mass index before pregnancy, maternal weight at delivery and maternal age), the offspring birth weight
and late pregnancy ultrasound parameters were still not associated with the maternal or fetal HSD11B2｛CA｝n microsatellite
polymorphisms. Conclusion Fetal and maternal HSD11B2 polymorphism is not related to fetal growth during normal
pregnancy.