Abstract: Objective To screen differentially expressed genes and identify potential signaling pathway in Asian people with
breast cancer. Methods Five gene microarray datasets of Asian people with breast cancer, GSE6367, GSE9309, GSE15852,
GSE33447 and GSE45255, were downloaded from GEO. Microarrays with 318 breast cancer and 60 normal breast tissues were
used for analysis of differentially expressed genes and pathway. 32 pairs of breast cancer patients’ specimens were used to
validate the differentially expressed genes by real-time PCR. Results Analysis of the large sample of microarray data identified
436 differentially expressed genes in breast cancer tissues, while 259 of these genes were up-regulated and the other 177
down-regulated. Pathway analysis showed that metabolism-related signaling pathway may be involved in the development of
breast cancer in Asian people. The expressions of KRT19, ADIPOQ, CFD, RBP4, LPL, ABCA8 and CD36 genes were confirmed
by real-time PCR. Conclusion This study shows differential gene expression profile and potential signaling pathway in Asian
people with breast cancer. CD36 gene may be closely related to the Asian breast cancer. ABCA8 gene may be a new disease
gene in Asian breast cancer.