Abstract: Objective To explore the value of the strain means of the quantitative parameters of organization diffusion in
determining the degree of liver fibrosis. Methods A total of 130 patients with chronic hepatitis B were examined for
quantitative analysis of organization diffusion before liver biopsy to analyze the performance of the strain means in liver
fibrosis of different degrees. All the cases were confirmed by pathology. Results The strain means differed significantly
between different stages of liver fibrosis. Using the best cut-off values of 116.2, 111.4, 101.6 and 97.5 for diagnosis of S≥1, S≥2,
S≥3 and S=4, the diagnostic sensitivities were 91.2%, 90.8%, 95.8% and 89.7%, with specificities of 90.4%, 98.6%, 93.8% and
95.6% and accuracies of 90.6% , 94.7% , 95.5% and 91.8% , respectively. Conclusion The strain mean can provide specific
numerical indicators to determine the degree of liver fibrosis.