Abstract: Objective To evaluate the renal function in treatment-naïve patients with hepatitis B virus (HBV) related cirrhosis
and to identify the risk factors for renal impairment. Methods We collected the data of 860 HBV-related cirrhosis patients
hospitalized in our unit between Jan 1, 2011 and Dec 31, 2011. Liver function of the patients was assessed with Child-Pugh
score system, and the renal function with estimated glomerular filtration rate (eGFR) calculated by Modification of Diet in
Renal Disease (MDRD) equation recommended by Kidney Disease Outcomes Quality Initiative (K/DOQI). We investigated the
prevalence of renal impairment (eGFR<60 ml/min/1.73 m2) among these patients and explored the risk factors for renal
impairment. Results Of the 860 patients, 296 had complete clinical data and were included in our analysis. The overall
incidence of renal impairment among the enrolled patients was 8.45% (25/296). Patients with Child-Pugh stage C showed a
significantly higher incidence of renal impairment than those with stages B and A (17.17% [17/99] vs 6.67%[7/105] vs 1.09% [1/
92], P<0.001). Age, history of hyperuricemia, and Child-Pugh score were identified as the risk factors for renal impairment in
these patients. Conclusion In patients with HBV-related liver cirrhosis, the incidence of renal impairment increases
significantly with deterioration of the liver function, and renal function should be regularly monitored in these patients for
appropriate antiviral treatment.