Journal of Southern Medical University ›› 2014, Vol. 34 ›› Issue (02): 169-.
Previous Articles Next Articles
Online:
Published:
Abstract: Objective To formulate a novel histological typing and grading-rated system for colorectal cancer (CRC) forevaluating the biological behavior of CRC and prognosis. Methods According to the highly heterogeneous histologicalfeatures, WHO classification and histological differentiation criteria, and other biological behavior parameters of CRC, a novelhistological typing and grading-scale system for CRC was designed. The histological typing and corresponding grading-scaleof CRC was defined as the following: (1) No mucin-producing adenocarcinoma, including tubular adenocarcinoma, sieve-likeacne adenocarcinoma, medullary carcinoma, serrated adenocarcinoma and micropapillary carcinoma, etc. (1-3 points); (2)Mucin-producing adenocarcinoma, including mucinous adenocarcinoma and signet ring cell carcinoma (3-4 points); (3)Squamous cell carcinoma (1-3 points); (4) Neuroendocrine tumors, including neuroendocrine tumors, neuroendocrinecarcinoma (1-4 points); (5) The special type of CRC, including clear cell carcinoma, spindle cell carcinoma, etc. (4-points); (6)Undifferentiated carcinoma (5 points). The pathology report form was formated based on the major histological type with thesecondary histological type. The final total score of CRC was defined as the sum of the corresponding grading scores fordifferent histological types. The total score of a single-structure CRC was defined as the corresponding grading scoremultiplied by 2. A total of 666 patients with advanced CRC were pathologically reviewed and analyzed to assess thecorrelation of the histological typing and grading scores with TNM staging and lymph node metastasis. Results The resultsshowed a significant correlation of the histological grading-scale and TNM staging and lymph node metastasis (P<0.05). Thescores of CRC histological grading-scale increased synchronously with the TNM staging and lymph node metastasis rate.Conclusion The novel histological grading system allows objective evaluation of the biological behaviors and prognosis ofCRC for determining individualized postoperative treatment. This system still needs further revision and updates based onevidence from prospective, multi-centered, large-scale trials.
0 / / Recommend
Add to citation manager EndNote|Ris|BibTeX
URL: https://www.j-smu.com/EN/
https://www.j-smu.com/EN/Y2014/V34/I02/169