Abstract: Objective To explore the expression of CDK6 in nasopharyngeal carcinoma (NPC) and explore its clinical
significance. Methods Immunohistochemistry was used to examine the differential expression of CDK6 protein in 101 NPC
and 30 nasopharyngeal tissues, and the correlation of CDK6 expression with the clinical characteristics was analyzed in NPC
cases. Results Immunohistochemistry demonstrated that CDK6 protein was a co-expressed factor in the cytoplasm and cell
nuclei. CDK6 was expressed predominantly in the cytoplasm in nasopharyngeal tissues, but in NPC tissues, CDK6 was
co-expressed predominantly in the cytoplasm and nuclei. Compared to the nasopharyngeal tissues, NPC tissues showed
significantly up-regulated CDK6 expression (P=0.009) in positive correlation with tumor size (P=0.020) and clinical stages (P=
0.0039). Conclusion Increased CDK6 protein expression is an unfavorable factor that promotes the development and
progression of NPC.