Abstract: Objective To study the effect of Jianpi Qinghua decoctions in ameliorating kidney fibrosis in rats with focal segmental
glomurular sclerosis (FSGS) nephropathy in light of blocking the functions of the inflammatory cells. Methods Rat models of
FSGS nephropathy were established by left nephrectomy and intravenous injection of adriamycin and treated with Jianpi
Qinghua decoction. The renal expressions of interleukin-6 (IL-6), monocyte chemotactic protein 1 (MCP-1), and intercellular
adhesion molecular-1 (ICAM-1) were detected. Results Treatment with Jianpi Qinghua decoction, Jianpi decoction, Qinghua
decoction, and Niaoduqing particles all significantly lowered renal tubulointerstitial expressions of IL-6 in the model rats (P<
0.01). Renal tubulointerstitial MCP-1 expressions were all lowered significantly in the rats by treatments with Jianpi Qinghua
decoction, Jianpi decoction, QingHua decoctions, and Niaoduqing particles (P<0.01), and Jianpi Qinghua decoction produced a
stronger effect than Niaoduqing particles (P<0.05). Jianpi Qinghua decoction, Jianpi decoction, Qinghua decoctionsand and
Niaoduqing particles all significantly decreased renal tubulointerstitial MCP-1 and ICAM-1 expressions (P<0.01), and Jianpi
Qinghua and Qinghua decoctions both showed stronger effects than Niaoduqing particles (P<0.01). Jianpi Qinghua
decoctionssignificantly suppressed the expressions of IL-6, MCP-1, and ICAM-1 and produced stronger effects than
Niaoduqing particles on MCP-1 and ICAM-1 expressions. Conclusion Jianpi Qinghua decoctions can ameliorate inflammatory
injury and lower the levels of inflammatory factors in rats with FSGS nephropathy, the mechanism of which is associated with
inhibiting IL-6 signaling pathway.