Abstract: Objective To evaluate the application value of three risk-stratification criteria in domestic GIST risk assessment.
Methods The clinical data of 144 patients with GIST who were admitted to our hospital from January 2008 to December 2010
were analyzed retrospectively. 144 cases of GISTs were evaluated for their biologic potential by the risk-stratification criteria of
Fletcher, NIH2008, and among those, 119 cases of GISTs were evaluated by the risk-stratification criteria of Miettinen. Fletcher
and Miettinen criteria were compared by Kaplan-Meier survival analysis. The Logistic regression model was established to
analyze the comparison of Miettinen and NIH2008 criteria. Results (1) According to Fletcher criteria in the intermediate risk
GISTs, the recurrence-free survival (RFS) of non gastric(small intestinal, rectal and so on) GISTs and gastric GISTs were
statistically different (P=0.001). According to Miettinen criteria, in the risk subgroup of GISTs，the recurrence-free survival of
different location of GISTs had no statistical difference(P>0.05); (2)Logistic regression model judgment rate: Miettinen criteria
(89.4)>NIH2008 criteria (85.2). Conclusion Fletcher criteria is simple and easy to use, but may misjudge the prognosis of the
GIST in different part; Miettinen criteria may be a potential supplementary way of NIH2008 criteria in domestic GIST risk
assessment.