Abstract: Objective To investigate the correlation of the occurrence and prognosis of coronary slow flow phenomenon (CSF)
with blood homocysteine (Hcy) levels in patients receiving emergency percutaneous coronary intervention therapy (PCI).
Methods From January, 2010 to December, 2011, 138 patients with ST-elevation myocardial infarction received emergency
angioplasty, among whom 46 patients developed CSF and 92 did not (control group). Blood Hcy levels were determined in
these patients. The patients with CSF were classified into two groups with mild and moderate Hcy elevations (32 and 14 cases,
respectively), and the left ventricular ejection fraction (LVEF) during hospitalization and at 3 months of follow-up as well as
major adverse cardiac events (MACE) were compared between the two groups and analyzed for their association with Hcy
level. Results The patients with CSF showed significantly higher blood Hcy levels than the control patients (P=0.001). At 3
months of follow-up, the patients with CSF and moderate Hcy elevation had significantly lower LVEF (P=0.031) and higher
incidence of MACE (P=0.019) than those with mild Hcy elevation. Hcy levels were negatively correlated with LVEF (r=-0.310,
P=0.036) and positively with MACE (r=0.342, P=0.02). Conclusion A high blood Hcy level is closely correlated with the
occurrence of CSF in emergency PCI, affects the recovery of LVEF and increases the incidence of MACE.