Abstract: Objective To investigate the age-related changes in resting functional connectivity of the marginal division (MrD) of
the neostriatum in healthy adults detected using resting-state functional magnetic resonance imaging (rs-fMRI). Methods
Forty-four healthy volunteers aged between 22 and 44 years (mean 30.36±6.31 years) and 20 elderly volunteers aged between
48-83 years (mean 61.4±10.25 years) underwent conventional MRI, 3D structural MRI and rs-fMRI. MrD was defined manually
on the structural images for computation of the functional connectivity maps. The single group data were analyzed with
independent sample t test, and the data of the two-group were examined by analysis of covariance with gender as the
covariance. Results In the young volunteers, the brain regions of functional connectivity related with the MrD were located in
bilateral middle cingulate gyri, putamen, thalamus and amygdala, as compared with the brain regions of the bilateral
putamen, thalamus, amygdala, insular cortex, rolandic operculum and right supramarginal gyrus in the elderly volunteers.
Compared with the young volunteers, the elderly volunteers showed decreased functional connectivity related with the MrD
in the bilateral middle cingulate gyri, parahippocampal gyri and left hippocampus. Conclusion An increased age is associated
with alterations in the functional connectivity related with the MrD in healthy adults.