Abstract: ObjectiveTo study the value of dynamic contrast-enhanced magnetic resonance imaging (MRI) in evaluating the
curative effect of high intensity focused ultrasound (HIFU) for hypersplenism.MethodsA retrospective analysis of dynamic
contrast enhanced MRI data was conducted in15patients with hypersplenism before and after HIFU treatment to observe the
signal changes and enhancement features of the lesions.ResultsCompared with that before treatment, the signal intensity of
the lesions after HIFU could be increased, reduced or remained unchanged on T1WI without specificity; on T2WI, the signal
intensity of the lesions was reduced after HIFU treatment. Dynamic contrast-enhanced MRI showed larger ablation areas than
those displayed by T1WI and T2WI, and no enhancement was found in the lesions.ConclusionT2WI has a greater specificity in
demonstrating coagulation necrosis of hypersplenism after HIFU ablation, and dynamic contrast-enhanced MRI has a higher
sensitivity in displaying the ablation area by highlighting the blood supply and enhancement characteristics of the lesions.
MRI is efficient and noninvasive in follow-up evaluation of the signal intensity as well as histological changes of the treated
region after HIFU.