Abstract: Objective To evaluate the clinical value of quantitative tissue velocity imaging(QTVI)in detection of regional wall movement abnormalities in patients with coronary artery disease(CAD).Methods The segmental left ventricular wall motion velocity was measured in 45 normal subjects and 48 patients with CAD,and the parameters of QTVI were analyzed between the two groups.Results Velocity decrement and wave form alterations were shown in abnormal segmental movements in the CAD group.There were obvious differences in the velocity between normal and abnormal segment.Conclusion QTVI is valuable in quantitative and sensitive evaluation of regional wall movement abnormalities for non-invasive diagnosis of CAD.