Effect of Tribulus terrestris extract on melanocyte-stimulating hormone expression in mouse hair follicles

Abstract

Abstract: Objective To observe the effect of Tribulus terrestris extract on melanocyte stimulating hormone(MSH)expression in C57BL/6J mouse hair follicles,and investigate the role of Tribulus terrestris extract in activation,proliferation,epidermal migration of dormant hair follicle melanocytes.Methods The aqueous extract of Tribulus terrestris was administered orally in specific pathogen-free C57BL/6J mouse at the daily dose equivalent to 1 g/1 kg in adult human,and the expression and distribution of MSH in the mouse hair follicles was observed with immunohistochemistry.Results The positivity rate of MSH expression in the hair follicle melanocytes was 75% in mice treated with the extract,significantly higher than the rate of only 18.75% in the control group(P<0.01).Conclusion The aqueous extract of Tribulus terrestris can significantly increase MSH expression in the hair follicle melanocytes by activating tyrosinase activity and promoting melanocyte proliferation,melanine synthesis,and epidermal migration of dormant melanocytes.

CLC Number:

R285

YANG Liu1,LU Jian-wei1,AN Jing2,JIANG Xuan1 1Department of Traditional Chinese Medicine,2Department of Histology and Embryology,Southern Medical University,Guangzhou 510515,China. Effect of Tribulus terrestris extract on melanocyte-stimulating hormone expression in mouse hair follicles[J]. Journal of Southern Medical University, 2006, 26(12): 1777-1779.

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Effect of Tribulus terrestris extract on melanocyte-stimulating hormone expression in mouse hair follicles

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