Abstract: Objective To evaluate the therapeutic efficacy of deoxyribonucleotidum in treatment of acute viral myocarditis. Methods Eighty-eight patients with acute viral myocarditis were randomized epually into therapeutic group and control group. Patients in the control group were treated with routine treatment and those in the therapeutic group were given deoxyribonucleotidum in addition to routine treatment. After 4 weeks, the total efficacy rate and median time of symptom disappearance were compared between the two groups. Results The total efficacy rate in the control and therapeutic groups was 79.54% and 95.45% (P=0.049), and the median time of symptom disappearance was 9.5 days and 6.5 days, respectively (P=0.035). Hypotension and mild dizziness were found in 2 patients in the therapeutic group without other severe side effects. Conclusion Deoxyribonucleotidum can improve the therapeutic effect for acute viral myocarditis.