Abstract: Objective To evaluate the therapeutic efficacy of intensity-modulated radiation therapy(IMRT) combined with Delisheng injection for treatment of nasopharyngeal carcinoma (NPC). Methods Sixty-six patients with pathologically confirmed NPC (stage Ⅱand Ⅲ) were randomized into therapeutic group and control group. Patients in the therapeutic group were treated with Delisheng injection in addition to IMRT and those in the control group with IMRT alone. Results No significant difference in the response rate occurred between the two groups. The incidence of adverse effects was significantly lower in the therapeutic group than in the control group, and the humoral immunity was improved in the former. Conclusion Delisheng injection can decrease the side effects of IMRT and improve humoral immunity in NPC patients.