Journal of Southern Medical University

Journal of Southern Medical University ›› 2006, Vol. 26 ›› Issue (06): 824-825.

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Oncogene ZNF217 amplification on chromosome 20 q in ovarian serous cystadenocarcinoma and its clinical implications

LI Jing, ZHONG Mei, SONG Lan-lin, SU Gui-dong Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China   

  1. 南方医科大学南方医院妇产科； 南方医科大学南方医院妇产科 广东广州510515； 广东广州510515；
  • Online:2006-06-20 Published:2006-06-20

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Abstract: Objective To investigate the amplification of zinc finger protein 217 (ZNF217) gene on chromosome 20 in ovarian cancer and its clinical significance. Methods Twenty-three specimens of ovarian carcinoma (11 cases of early stage and 12 advanced stage), 10 specimens of benign ovarian tumors and 7 normal ovaries were examined for ZNF217 gene amplification on chromosome 20 by fluorescence in situ hybridization (FISH). Results ZNF217 gene amplification was detected in 12 cases of ovarian cancer (52.17%) and 1 case of benign ovarian tumor, but not in normal ovary. ZNF217 amplification was significantly associated with ovarian cancer. Conclusion Oncogene ZNF217 is associated with the tumor stage and poor prognosis of patients with ovarian cancer. 更多

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