Abstract: Objective To investigate the expression and clinical implication of tissue inhibitor of metalloproteinase-1(TIMP-1)in colorectal carcinoma.Methods TIMP-1 expression in 54 colorectal carcinoma was observed by SP immunohistochemical method,and the results were analyzed in relation to the clinical data of patients.Results TIMP-1 was localized on the membrane and in the cytoplasm of the enteric epithelial cells,and its expression rate was 100% in normal tissue but only 59.6%(31/52)in colorectal carcinoma tissues.In addition,the expression rate of TIMP-1 was higher in the tumor tissues without lymph node metastasis than in tissues with lymph node metastasis(P<0.05).Conclusion The expression of TIMP-1 is inversely correlated to lymph node metastasis of colorectal carcinoma,and decreased TIMP-1 expression may play a role in the progression of colorectal carcinoma.