Abstract: Objective To explore the clinical significance of early diagnose and treatment of subclinical renal allograft rejection.Methods Ninety-six renal allograft recipients(54 male and 42 female)with normal renal function aged 17 to 58 years(mean 37.5 years)were included in this study.Early subclinical rejection was diagnosed 3 months after the transplantation by color Doppler examination.Results Patients with early subclinical rejection were given methylpredisolone followed by adjustment of immunosuppressive regimens,and no difference was observed in 3-year survival rate between these patients and those with normal renal allograft findings.Conclusion Early diagnosis and treatment of subclical renal allograft rejection is significant to improve renal allograft survival rate.