Efficacy of Avastin in combination with irinotecan for metastatic colorectal cancer

Abstract

Abstract: Objective To evaluate the efficacy of Avastin in combination with irinotecan for metastatic colorectal cancer.Methods Ninety patients were randomly divided into 3 equal groups to receive Avastin plus irinotecan(group A),FOLFIRI(group B)and FOLFOX7(group C)for two cycles,respectively.The response rate and changes in tumor maker levels were observed.Results The tumor response rate was 43.3% in group A,27.7% in group B and 30.0% in group C.The disease control rate(complete response+partial response+stable disease)was 80% in group A,53.3% in group B and 50.0% in group C.Obvious changes in tumor marker levels were observed in the 3 groups after treatment,which were most conspicuous in group A(P<0.05).Conclusion The addition of Avastin to irinotecan chemotherapy results in significant improvement of clinical efficacy in patients with metastatic colorectal cancer.

CLC Number:

R735.3

ZHENG Hang,CHEN Jin-zhang,LIAO Wang-jun,LUO Rong-cheng Center of Oncology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China. Efficacy of Avastin in combination with irinotecan for metastatic colorectal cancer[J]. Journal of Southern Medical University, 2006, 26(05): 689-691.

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