Abstract: Objective To evaluate the clinical effect of eschar grinding and wound coverage by biological dressing A in the management of deep partial-thickness burn wound on the extremities.Methods Seventy-three patients with deep partial-thickness burns on the extremities were divided into two groups to receive different managements.The patients in group 1 were treated with eschar grinding and wound coverage with biological dressing A,and group 2 received conventional treatment.The white blood cell count,body temperature,incidence of wound infection and wound healing time were observed.Results Compared with conventional treatment,wound management with eschar grinding and coverage by biological dressing A could increase the effective rate(29/32 vs 31/41,P<0.05),inhibit systemic inflammation and scar hypertrophy,and shorten the wound healing time(13.79±5.72 vs 17.08±8.39,P<0.01).Conclusion Eschar grinding and wound coverage by biological dressing A can be effective for management of deep partial-thickness burns on the extremities,and earlier treatment with the dressing A achieves better effect.