Journal of Southern Medical University ›› 2006, Vol. 26 ›› Issue (05): 654-657.

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Establishment of hepatic metastatic subline of nasopharyngeal carcinoma cell line

HAN Chun,WANG Shuang,LIU Li,YAO Kai-tai Department of Pathology,Southern Medical University,Guangzhou 510515,China   

  1. 南方医科大学病理教研室; 南方医科大学病理教研室 广东广州510515; 广东广州510515;
  • Online:2006-05-20 Published:2006-05-20

Abstract: Objective To establish a hepatic metastatic subline of nasopharyngeal carcinoma(NPC)cell line.Methods NPC cells metastatic to the liver were isolated from nude mice and the invasion and metastatic ability of the cells was observed in vivo and in vitro.Results and Conclusion The invasion and metastasis activity of 5-8F-H3B-EGFP(an in vivo isolate with enhanced liver metastatic behaviors)were enhanced obviously in comparison with the parent cell line 5-8F-EGFP.This subline may be useful for cloning genes related to liver metastasis of NPC.

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