Journal of Southern Medical University

Journal of Southern Medical University ›› 2006, Vol. 26 ›› Issue (05): 648-650.

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Selective determination of dopamine in the presence of high concentration of ascorbic acid with L-cysteine modified glassy carbon electrodes

MA Xin-ying1,CHAO Zhi2,LI Xia1,XU He-yun1,ZHANG Guo-rong3 1Department of Chemistry,Heze University,Heze 254015,China;2School of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China;3College of Chemistry and Chemical Engineering Material Science,Shandong Normal University,Jinan 250014,China   

  1. 菏泽学院化学与化工材料系； 南方医科大学中医药学院； 山东师范大学化学与化工材料学院 山东菏泽254015； 广东广州510515； 山东菏泽254015； 山东济南250014；
  • Online:2006-05-20 Published:2006-05-20

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Abstract: Objective To establish an assay system for determination of dopamine(DA)in the presence of ascorbic acid(AA)with L-cysteine modified glassy carbon electrode.Methods L-cysteine was modified onto glassy carbon electrode electrochemically,and with this modified electrode,dopamine was determined by linear sweep stripping voltammetry.Results L-cysteine polymer-modified electrode had strong catalytic effect towards the electrochemical oxidation of DA.The modified electrode showed good properties in determination of DA with coexisting AA.Under selected conditions,the linearity of DA was in the range of 2.0×10-7～1.0×10-4 mol/L with the detection limit of 2.0×10-8mol/L.The stability,reliability and recovery of this L-cysteine-modified electrode based on electrochemical method were also satisfactory.Conclusion L-cysteine-modified electrode can avoid the interference by AA for determination of DA.

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