Abstract: Objective To establish an porcine model of whole pancreaticoduodenal transplantation with portal venous drainage and enteric drainage for ensuring physiologically normal function without hyperinsulinemia and reducing postoperative complications.Methods Twenty sichuan native outbreding white pigs weighing 25-30 kg were divided equally into two groups to serve as the donors and recipients.Cooling of the grafts was accomplished with in situ flush with 4℃ UW preservation solution via an aortic cannula.A whole pancreatoduodenal graft with the segment of abdominal aorta and the portal vein was harvested from the donor pigs.Type Ⅰdiabetes model was established by complete removal of the recipient pancreas.The whole pancreatoduodenal graft was preserved and shaped in UW solution,and the subphrenic abdominal aorta of the recipient was joined with the donor abdominal aorta via a side-to-end anastomosis,and venous reflux was reconstructed between the donor portal vein and the recipient superior mesenteric vein.Side-to-side intestinal anastomosis was performed between the donor duodenum and the recipient jejunum.Results Ten pancreaticoduodenal transplantations(PVE+ED style)were done,and pancreatic graft thrombosis and embolism occurred only in 1 pig 6 days after transplantation.Conclusion The model of whole pancreaticoduodenal transplantation with portal venous drainage and enteric drainage is stable and reliable.