Quantitative study of dynamic magnetic resonance perfusion-weighted imaging in rabbit models of implanted hepatic VX2 tumor

Abstract

Abstract: Objective To investigate the possibility of dynamic magnetic resonance(MR)perfusion-weighted imaging(PWI)in rabbit models of implanted hepatic VX2 tumor.Methods MRI and PWI images were obtained from 16 rabbit models of implanted hepatic VX2 tumor and 4 normal rabbits at 14,18,22,and 26 days after tumor implantation,respectively,and the mean time to enhancement(MTE)and maximum slope of increase(MSI)were estimated and compared with pathological changes.Results In the rabbit models of implanted hepatic tumor the MTE tended to increase and MSI to descend 14,18,22,and 26 days after tumor implantation,showing significant differences from the control group.Coagulation necrosis and fibrous hyperplasia in the tumors appeared to progress with time as found pathologically.Conclusion Dynamic MR PWI quantitative analysis of rabbit models of implanted hepatic VX2 tumor provides valuable means for observing the growth behaviors of VX2 tumor and may be clinically applicable in the evaluation of hepatic diseases.

CLC Number:

R735.7

QUAN Xian-Yue1,ZHANG Xue-Lin2,SUN Xi-Jie1,Xing Hai-Fang3,LIANG Wen1 1Imaging Center,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China;2Diagnositic Imaging Center,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;3GE(China)Medical System,Guangzhou 510060,China. Quantitative study of dynamic magnetic resonance perfusion-weighted imaging in rabbit models of implanted hepatic VX2 tumor[J]. Journal of Southern Medical University, 2006, 26(05): 620-622.

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[2]	. [J]. Journal of Southern Medical University, 2006, 26(12): 1736-.
[3]	. [J]. Journal of Southern Medical University, 2006, 26(12): 1826-1827.
[4]	XU Zhuo-ming1,WANG Jun-hua1,ZHEN Zuo-jun1,CHEN Huan-wei1,CUI Wei-zhen2 1Department of Hepatobiliary Surgery,2Department of Ultrasonography,First People’s Hospital of Foshan City,Foshan 528000,China. Percutaneous radiofrequency ablation combined with transcatheter arterial chemoembolization and percutaneous ethanol injection for recurrent small hepatocellular carcinoma [J]. Journal of Southern Medical University, 2006, 26(11): 1626-1628.
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[6]	. [J]. Journal of Southern Medical University, 2006, 26(11): 1675-1676.
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Quantitative study of dynamic magnetic resonance perfusion-weighted imaging in rabbit models of implanted hepatic VX2 tumor

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