Abstract: Objective To establish a pig model of chronic external counterpulsation.Methods Twelve pigs were anaesthetized with sodium pentobarbital(≤30 mg/kg·b.w.)and 846 mixture(≤0.1 ml/kg·b.w.)and counterpulsed in a lateral position for 2 h every two days(totally 36 h)with 0.025 to 0.04 MPa/cm2 pressure.Results External counterpulsation was successfully completed in all the animals.Combined administration of sodium pentobarbital and 846 mixture resulted in good anesthetic effect with reduced anesthetic dosage and minimal side effect on the viscera(the liver,kidney and heart,etc).Conclusion The pig model of chronic external counterpulsation has been successfully established.Combined use of sodium pentobarbital and 846 mixture is recommended for chronic external counterpulsation.