Abstract: Objective To investigate the clinicopathological features of nonalcoholic steatohepatitis(NASH) and elucidate its diagnosis and differential diagnosis.Methods Liver biopsy tissues and clinical data of 32 patients with NASH were collected and the clinicopathological findings by HE and Masson staining were evaluated for NASH grading.Results Ballooning degeneration of the liver cells and fibrosis around hepatic sinusoid was scarce in mild NASH cases and increased in moderate to severe cases.Steatotic and inflammatory cells in the liver lobes decrease in liver cirrhosis related to seatohepatitis.Conclusion Ballooning degeneration of the liver cells and fibrosis around the hepatic sinusoid have important value in differential diagnosis of mild from moderate to severe NASH,and correct histological grading benefits clinical intervention and prognostic evaluation of NASH.