Abstract: Objective To study the effect of the S-bioallethrin on human lymphocytes by microarray technique.Methods The changes of normal human lymphocytes treated with S-bioallethrin were examined with light microscope,flow cytometry,electron microscope,DNA ladder and microarray techniques.Results Morphological study showed that the lymphocytes underwent apoptosis after S-bioallethrin exposure,which as further confirmed by the expression changes of 346 genes.Conclusion S-bioallethrin can induce apoptosis of normal human lymphocytes and changes in their gene expression profiles.