Abstract: Objective To investigate the application of flexible bronchoscopy in the postoperative management of lung transplantion. Methods Four male patients with end-stage chronic obstructive pulmonary disease received examination with bronchoscope following the unilateral lung transplant for management of airway complications. One patient developed stenosis at tracheal anastomosis 2 months after transplantion and underwent balloon dilatation and endobronchial metallic stent placement. Results The 4 patients showed good recovery after transplantation with obviously improved pulmonary function and quality of life. Conclusion Flexible bronchoscopy provides a valuable means for postoperative management of lung transplantation.