Journal of Southern Medical University ›› 2005, Vol. 25 ›› Issue (11): 1441-1442,1447.

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Effects of benazepril combined with valsartan on congestive heart failure

YE Jian-feng, LIU Dong-sheng   

  1. 东莞市人民医院心内科, 广东, 东莞, 523018
  • Online:2005-11-20 Published:2005-11-20

Abstract: Objective To observe the effects of routine doses of benazepril combined with valsartan on congestive heart failure. Methods Totally 203 patients with congestive heart failure were randomized into Group A (receiving benazepril 20 mg/day), Group B (benazepril,10 mg/day plus valsartan, 80 mg/day), and group C (valsartan 160 mg/day) for different treatment protocols on the basis of routine therapy for heart failure with digitalis, diuretics and β blockers. The cardiac functions and echocardiographical findings were evaluated before and after the treatments. Results All the patients showed improvement of NYHA class, left ventricular end-diastolic dimension (LVEDd), left ventricular end-systolic dimension (LVESd) and left ventricular ejection fraction (LVEF) (P<0.01), and the effect was better in group B than in group A (P>0.05), and both groups A and B had better results than group C (P<0.05). No serious adverse effects were found. Conclusion The combination of benazepril and valsartan at routine doses can be effective for treating congestive heart failure.

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