Abstract: Objective To evaluate therapeutic effects of endovenous laser treatment (ELT) and subfascial endoscopic perforator surgery (SEPS) in the treatment of venous leg ulcer (VLU). Methods ELT and SEPS were performed in 10 patients with VLU (involving 10 legs). Among them, external valvuloplasty was performed in 4 legs with deep venous valve insufficiency. Results Ulcer of the 10 legs healed within 10-60 days after the operation, and follow-up study ranging from 2 to 8 months with the average of 6 months revealed no recurrences. Conclusion ELT combined with SEPS provides an effective approach for VLU treatment with minimal invasion, and when combined with external valvuloplasty, this approach may effectively reduce ulcer recurrence.