Abstract: Objective To evaluate the therapeutic effects of nasal endoscopic surgery combined with multiple radiofrequency in the treatment of perennial allergic rhinitis. Methods Sixty-three patients with perennial allergic rhinitis whose symptoms failed to be controlled by medication received nasal endoscopic surgery for submucous resection of the nasal septum combined with radiofrequency ablation of the bilateral sphenopalatine foramen,anterior ethmoidal nerve and inferior nasal concha. Result One month after operation,the rate of excellent recovery was 92.1% (58/63),efficacy rate of 7.9% (5/63),and total efficacy rate of 100%,which was 88.9%(56/63),7.9%(5/63),and 96.8% (61/63) 1 year after operation,respectively,with 2 patients (3.2%) of the patients failed to respond to the treatment.Two years after the operation,the excellent rate,efficacy rate,and total effective rate was 82.6%(52/63),12.7%(8/63),and 95.2% (60/63),respectively,with 3 patients failed to obtain good recovery. Conclusion Nasal endoscope combined with radio frequency may achieve good therapeutic effects on perennial allergic rhinitis with less adverse effects.