Abstract: Objective To observe the therapeutic effect and safety of terbinafine in treating onychomycosis in chidren.Methods Terbinafine was used to treat 50 children with fingernail onychomycosis and 38 with toenail onychomycosis, and the efficacy, fungal clearance and safety of the drug were evaluated.Results The clinical cure rate and total effective rate were 92.1% and 97.37%, respectively, for fingernail onychomycosis, and 86.36% and 93.94% for toenail onychomycosis, with fungal clearance rate of 96.59%. No serious side-effects was observed in the children receiving terbinafine therapy.Conclusion Terbinafine is effective and safe for the treatment of onychomycosis in children.