Expressions of Aβ1-40, Aβ1-42, tau202, tau396 and tau404 after intracerebroventricular injection of streptozotocin in rats

Abstract

Abstract: Objective To investigate the effects of intracerebroventricular(ICV) administration of streptozotocin(STZ) on the expressions of Aβ and hyperphosphorylation of tau protein in rat brain. Methods Twenty-four adult SD rats were randomized into 2 groups to receive ICV of STZ bilaterally at the dose of 3 mg/kg(with the injection repeated on day 3) or normal saline injection in an identical manner. Twenty-one days later, the expressions of Aβ_1-40,Aβ_1-42, tau²⁰², tau³⁹⁶ and tau⁴⁰⁴ were investigated immunohistochemically. Results After STZ administration, the expressions of Aβ_1-40,Aβ_1-42, tau²⁰², tau³⁹⁶ and tau⁴⁰⁴ increased in both the cortex and hippocampus in the rat brain. Conclusion ICV injection of STZ increases the expression of Aβand promotes hyerphosphorylation of tau protein.

CLC Number:

R749.1

CHU Wen-zheng, QIAN Cai-yun. Expressions of Aβ_1-40, Aβ_1-42, tau²⁰², tau³⁹⁶ and tau⁴⁰⁴ after intracerebroventricular injection of streptozotocin in rats[J]. Journal of Southern Medical University, 2005, 25(02): 168-170,173.

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Expressions of Aβ_1-40, Aβ_1-42, tau²⁰², tau³⁹⁶ and tau⁴⁰⁴ after intracerebroventricular injection of streptozotocin in rats

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[1]	. [J]. Journal of Southern Medical University, 2006, 26(11): 1582-1583.
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