Detection of amino acid neurotransmitters in cerebrospinal fluid of patients in persistent vege-tative state

Abstract

Abstract: Objective To detect the amino acid neurotransmitters in cerebrospinal fluid of patients in persistent vegetative state (PVS) to define their relation to the clinical manifestations of the patients. Methods The cerebrospinal fluid from 46 patients in PVS and 20 control patients were collected for detection of glutamic acid, aspartic acid, alanine and glycine by high-performance liquid chromatography. Results All the four amino acids were separated by chromatography within 25 min. The contents of all the 4 neurotransmitters in PVS group were higher than those in the control group, and their contents were inversely correlated to PVS score of the patients. The differences in the concentration of glycine and alanine were significant between PVS patients and the control patients (P<0.05). Conclusion The patient’s clinical manifestations are related to the contents of amino acid neurotransmitters in the cerebrospinal fluid of PVS patients.

CLC Number:

GUO Yan-wu, XU Ru-xiang. Detection of amino acid neurotransmitters in cerebrospinal fluid of patients in persistent vege-tative state[J]. Journal of Southern Medical University, 2005, 25(01): 71-74.

References

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